Antitumoral Action of Resveratrol Through Adenosinergic Signaling in C6 Glioma Cells

Gliomas are the most common and aggressive primary tumors in central nervous system. The nucleoside adenosine is considered to be one major constituent within tumor microenvironment. level mainly depends on two enzymatic activities: 5′-nucleotidase (5′NT or CD73) that synthesizes from AMP, deaminase (ADA) converts into inosine. Adenosine activates specific G-protein coupled receptors named A 1 , 2A 2B 3 receptors. Resveratrol, a natural polyphenol present grapes, peanuts, berries, shows several healthy effects, including protection against cardiovascular, endocrine, neurodegenerative diseases cancer. However, molecular mechanisms of resveratrol actions not well known. Recently, we demonstrated acts as an agonist for rat C6 glioma cells. work aimed investigate involvement metabolism underlying antitumoral action resveratrol. Results presented herein show was able decrease cell numbers viability reduce CD73 ADA activities, leading increase extracellular levels. Some effects were reduced by blockade DPCPX MRS1220, respectively. These results suggest activity located plasma membrane addition fine-tuned modulatory role could involved, at least part, antiproliferative